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      Cardiovascular Responses to Carotid Occlusion and Central Vagal Stimulation

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          Abstract

          Heart-rate (HR) and systolic-pressure (SP) responses to unilateral and bilateral carotid occlusion (BCO) and to central vagal stimulation were measured in control anesthetized dogs, after bilateral vagotomy, and after extensive disruption of the neuraxis by RF lesions. Preocclusion HR was significantly increased after vagotomy, with no change in SP. Lesions had no effect on resting HR, but they decreased SP. HR response to BCO was unchanged after vagotomy, but decreased almost 50% after lesions. The SP response to BCO increased greatly after vagotomy and returned to control levels after lesions. The response in HR and SP to unilateral right carotid occlusion (RCO) was larger than that to left carotid occlusion (LCO) under all experimental conditions. The summed response to RCO + LCO did not equal the BCO response. Supramaximal stimulation of the left central vagus evoked larger responses in HR and SP than the right vagus before lesions, but only HR responses were larger after lesions. It is suggested that the integrative mechanisms involved have some independent central connections, and that they are modulated by a complex control system which includes CNS levels above the mesencephalon.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1972
          1972
          29 October 2008
          : 57
          : 4
          : 212-231
          Affiliations
          Department of Physiology, Stritch School of Medicine, Graduate School, Loyola University, Maywood, Ill.
          Article
          169521 Cardiology 1972;57:212–231
          10.1159/000169521
          5074758
          © 1972 S. Karger AG, Basel

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          Pages: 20
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