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      The Albert Lasker Medical Awards. RU-486 as an antiprogesterone steroid. From receptor to contragestion and beyond.

      1
      JAMA
      Genetics and Reproduction

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          Abstract

          The steroid RU-486 (mifepristone) is an antiprogesterone that works at the receptor level. It can interrupt pregnancy very early on (contragestion), mostly by interfering with the process of implantation and decidua function. It also may facilitate surgical evacuation of the uterus and certain difficult deliveries. It impedes ovulation when taken during the follicular phase. Also, RU-486 is the first antiglucocorticosteroid available for clinical use. It deserves further studies to assess its wide range of therapeutic potential.

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          Author and article information

          Journal
          JAMA
          JAMA
          0098-7484
          0098-7484
          Oct 6 1989
          : 262
          : 13
          Affiliations
          [1 ] Lab Hormones, Institut National de la Santé et de la Recherche Médicale, Bicétre, France.
          Article
          2674487
          a046ab4a-eabd-499a-a3c7-a9aec653e722
          History

          Genetics and Reproduction
          Genetics and Reproduction

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