The Role of Tissue-Fixed Macrophages in Apoptosis in the Developing Kidney

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Abstract

Programmed cell death (PCD) and cell type involving dying cells in the developing mouse and human fetal kidneys were investigated using the modified TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method in combination with immunohistochemistry. We identified many TUNEL-positive apoptotic cells mainly in the nephrogenic region in the developing mouse and human fetal kidneys. Tissue-fixed macrophages were widely distributed throughout the developing mouse and human fetal kidneys, including the nephrogenic zone. Most of the apoptotic cells in the nephrogenic zone were phagocytosed by tissue-fixed macrophages, suggesting that tissue-fixed macrophages play an important role in the process of PCD in the developing mouse kidney and human fetal kidney.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 23 December 2008

Volume: 77

Issue: 3

Pages: 325-332

Affiliations

Department of Pediatrics, Okayama University Medical School, Okayama, Japan

Article

Publisher ID: 190296 Other ID: Nephron 1997;77:325–332

DOI: 10.1159/000190296

PubMed ID: 9375828

SO-VID: a049a2b5-0c4b-479d-97cd-56cf8944dff6

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The Role of Tissue-Fixed Macrophages in Apoptosis in the Developing Kidney

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Karger: Nephrology

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