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      Experimental Eye Infections Caused by Pseudomonas aeruginosa

      , ,
      Ophthalmic Research
      S. Karger AG
      Microscopy, Pseudomonas aeruginosa, Corneal wound, Ulceration

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          Cells of Pseudomonas aeruginosa were titered (1.0× 10<sup>4</sup>–1.0× 10<sup>8</sup> cells) to determine the minimum number required to initiate corneal infection in Swiss-Webster and BALB/c mice. No infection was produced in either strain of mouse by direct application of the organisms to unwounded corneas. However, wounding the cornea in either strain followed by application of the bacteria (1 × 10<sup>7</sup>–1 × 10<sup>8</sup> cells) produced corneal infection within 18–24 h. In Swiss-Webster mice, corneal morphology appeared normal within 4–6 weeks. However, in BALB/c mice, changes occurred by 12–15 days post-infection resulting in micro-ophthalmia. The results suggest development of an experimental model to comparatively study the natural immune mechanism of the eye to bacterial challenge.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 8
          : 4
          : 311-318
          Departments of Anatomy, Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Mich
          264837 Ophthalmic Res 1976;8:311–318
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 09 March 1976
          : 24 June 1976
          Page count
          Pages: 8

          Vision sciences,Ophthalmology & Optometry,Pathology
          Microscopy,Corneal wound,Ulceration,Pseudomonas aeruginosa


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