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      Human Epidermis Reconstructed on Dermal Substrates in vitro: An Alternative to Animals in Skin Pharmacology

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          Abstract

          In this review, we describe three models of epidermis reconstructed on dermal substrates and utilized as an alternative to animal models. An almost normal epidermis is obtained when culture conditions are created that mimic the physiological conditions. The reconstruction of this epidermis allows us to evaluate the effects of substances such as retinoids and hormones on their target cell, namely the epidermal keratinocyte, and to vizualize the alteration of morphogenesis and architecture of the epidermis under the influence of such hormones. These cultures of reconstructed epidermis on firm substrates lifted to the air-liquid interface show a great potential in medical and pharmacological research since the systemic and topical actions of drugs as well as their metabolism can be studied.

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          Author and article information

          Journal
          SPP
          Skin Pharmacol Physiol
          10.1159/issn.1660-5527
          Skin Pharmacology and Physiology
          S. Karger AG
          978-3-8055-5283-7
          978-3-318-01507-2
          1660-5527
          1660-5535
          1990
          1990
          31 March 2009
          : 3
          : 2
          : 70-85
          Affiliations
          Département de Biologie Cellulaire, Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Valbonne, France
          Article
          210854 Skin Pharmacol 1990;3:70–85
          10.1159/000210854
          a05ce7f0-2792-4e0a-b3a2-a2f4a732298e
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 16
          Categories
          Paper

          Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
          Skin pharmacology,Dermal substrates,Epidermis reconstructed in vitro

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