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      Role of Corpus luteum Function in Embryo Implantation

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          The present study was undertaken to evaluate the role of corpus luteum function in the implantation process of cryopreserved embryos. Six patients with tubal infertility were studied, with a total of 27 fresh embryos being replaced following controlled ovarian hyperstimulation and in vitro fertilization. These embryo transfers failed to produce pregnancy. From the patients, 22 supernumerary embryos were cryopreserved and 10 viable frozen-thawed embryos were transferred in a subsequent natural cycle, resulting in 2 pregnancies. In 1 of the pregnancies, the serum concentrations of estradiol (E<sub>2</sub>) and progesterone (P<sub>4</sub>) in the midluteal phase were 29 pg/ml and 5.6 ng/ml, respectively. These values were considered to be below the physiological range. These data suggest that a pregnancy can be achieved in spite of low circulating E<sub>2</sub> and P<sub>4</sub> levels during the luteal phase, which are generally indicative of the luteal phase defect.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 37
          : Suppl 1
          : 75-78
          aDepartment of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa General Hospital, Chiba; bDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo; cDepartment of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan
          182358 Horm Res 1992;37:75–78
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 4
          New Aspects of the Physiology and Pathology of the Luteal Phase


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