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      Catechol-O-Methyltransferase and Dopamine- β-HydroxyIase Activity in the Blood Vessels of Hypertensive Rats

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          Abstract

          Catechol-O-methyltransferase (COMT) activity was measured in the aorta and mesenteric arteries of hypertensive rats. In both spontaneously hypertensive rats (SHR) and uninephrectomized-DOCA salt treated hypertensive rats COMT activity per milligram vascular protein increased. The elevated COMT specific activity may be compensatory to the increased blood pressure and serve to increase catecholamine degradation. In contrast to the degradative enzyme, the activity per milligram vascular protein of a synthetic enzyme, dopamine- β-hydroxylase (DBH) decreased by 50% in the mesenteric artery of the SHR. We suggest the possibility that in some types of hypertension both the enzymes of synthesis and degradation may be altered simultaneously to regulate neurotransmitter activity.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1974
          1974
          18 September 2008
          : 11
          : 3
          : 101-109
          Affiliations
          Pharmacology Section, Roche Institute of Molecular Biology, Nutley, NJ.
          Article
          158004 Blood Vessels 1974;11:101–109
          10.1159/000158004
          a06b5784-4b99-47ab-bf63-c6cfaf33995e
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 28 February 1974
          : 22 March 1974
          Page count
          Pages: 9
          Categories
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Hypertension,Catechol-O-methyltransferase,Blood vessels,Dopamine-<italic>&beta;</italic>-ydroxylase,Catecholamines

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