+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Catechol-O-Methyltransferase and Dopamine- β-HydroxyIase Activity in the Blood Vessels of Hypertensive Rats


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Catechol-O-methyltransferase (COMT) activity was measured in the aorta and mesenteric arteries of hypertensive rats. In both spontaneously hypertensive rats (SHR) and uninephrectomized-DOCA salt treated hypertensive rats COMT activity per milligram vascular protein increased. The elevated COMT specific activity may be compensatory to the increased blood pressure and serve to increase catecholamine degradation. In contrast to the degradative enzyme, the activity per milligram vascular protein of a synthetic enzyme, dopamine- β-hydroxylase (DBH) decreased by 50% in the mesenteric artery of the SHR. We suggest the possibility that in some types of hypertension both the enzymes of synthesis and degradation may be altered simultaneously to regulate neurotransmitter activity.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 11
          : 3
          : 101-109
          Pharmacology Section, Roche Institute of Molecular Biology, Nutley, NJ.
          158004 Blood Vessels 1974;11:101–109
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Research Paper


          Comment on this article