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      Rapid Correction of Metabolic Acidosis in Chronic Renal Failure: Effect on Parathyroid Hormone Activity

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          Abstract

          To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO<sub>2</sub>, sodium, serum total calcium and 1,25(OH)<sub>2 </sub>vitamin D<sub>3</sub> levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1994
          1994
          17 December 2008
          : 67
          : 4
          : 419-424
          Affiliations
          aDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, and bDepartment of Medicine, Chung Shan Hospital, Taipei, Taiwan, ROC
          Article
          188015 Nephron 1994;67:419–424
          10.1159/000188015
          7969674
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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