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      Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans.

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          Abstract

          The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematode Caenorhabditis elegans has been widely used and has provided valuable knowledge in determining the regulatory mechanisms driving the aging process. Many genes involved in lifespan regulation are associated with metabolic pathways and are influenced by genetic and environmental factors. In line with this, C. elegans provides a promising platform to study such gene by environment interactions, in either a reverse or forward genetics approach. In this review, we discuss longevity mechanisms related to metabolic networks that have been discovered in C. elegans. We also highlight the use of wild populations to study the complex genetic basis of natural variation for quantitative traits that mediate longevity.

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          Author and article information

          Journal
          Biochim. Biophys. Acta
          Biochimica et biophysica acta
          Elsevier BV
          0006-3002
          0006-3002
          Sep 15 2017
          Affiliations
          [1 ] Laboratory Genetic Metabolic Diseases, Academic Medical Center of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
          [2 ] Laboratory of Nematology, Wageningen University and Research, 6708 PB Wageningen, The Netherlands.
          [3 ] Laboratory Genetic Metabolic Diseases, Academic Medical Center of Amsterdam, 1105 AZ Amsterdam, The Netherlands. Electronic address: r.h.houtkooper@amc.nl.
          Article
          S0925-4439(17)30321-6
          10.1016/j.bbadis.2017.09.006
          28919364
          a08ae49f-7ce2-4385-8c63-cb61e81ef292
          History

          C. elegans,Aging,Forward genetics,Gene×environment interaction,Metabolism,QTL mapping

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