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Bulky biaryl phosphine ligands facilitate Pd-catalyzed C-O coupling reactions of aryl
halides with primary and secondary alcohols by promoting reductive elimination at
the expense of beta-hydride elimination. The key to their success is the ability to
match the size of the ligand to that of the combination of substrates. The efficient
coupling of a number of unactivated aryl chlorides and bromides with cyclic and acyclic
secondary alcohols was achieved. This included the coupling of allylic alcohols for
the first time in a Pd-catalyzed coupling process.