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Highly efficient nonrigid motion‐corrected 3D whole‐heart coronary vessel wall imaging

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      To develop a respiratory motion correction framework to accelerate free‐breathing three‐dimensional (3D) whole‐heart coronary lumen and coronary vessel wall MRI.


      We developed a 3D flow‐independent approach for vessel wall imaging based on the subtraction of data with and without T2‐preparation prepulses acquired interleaved with image navigators. The proposed method corrects both datasets to the same respiratory position using beat‐to‐beat translation and bin‐to‐bin nonrigid corrections, producing coregistered, motion‐corrected coronary lumen and coronary vessel wall images. The proposed method was studied in 10 healthy subjects and was compared with beat‐to‐beat translational correction (TC) and no motion correction for the left and right coronary arteries. Additionally, the coronary lumen images were compared with a 6‐mm diaphragmatic navigator gated and tracked scan.


      No significant differences ( P > 0.01) were found between the proposed method and the gated and tracked scan for coronary lumen, despite an average improvement in scan efficiency to 96% from 59%. Significant differences ( P < 0.01) were found in right coronary artery vessel wall thickness, right coronary artery vessel wall sharpness, and vessel wall visual score between the proposed method and TC.


      The feasibility of a highly efficient motion correction framework for simultaneous whole‐heart coronary lumen and vessel wall has been demonstrated. Magn Reson Med 77:1894–1908, 2017. © 2016 International Society for Magnetic Resonance in Medicine

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            Author and article information

            [ 1 ]King's College London, Division of Imaging Sciences and Biomedical Engineering LondonUnited Kingdom
            [ 2 ] Centre for Medical ImagingUniversity College London LondonUnited Kingdom
            [ 3 ]Pontificia Universidad Católica de Chile, Escuela de Ingeniería SantiagoChile
            Author notes
            [* ]Correspondence to: Gastão Cruz, Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, United Kingdom. E‐mail: gastao.cruz@
            Magn Reson Med
            Magn Reson Med
            Magnetic Resonance in Medicine
            John Wiley and Sons Inc. (Hoboken )
            25 May 2016
            May 2017
            : 77
            : 5 ( doiID: 10.1002/mrm.v77.5 )
            : 1894-1908
            27221073 5412916 10.1002/mrm.26274 MRM26274
            © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

            This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

            Figures: 7, Tables: 2, Pages: 15, Words: 7034
            Funded by: MRC
            Award ID: MR/L009676/1
            Funded by: BHF
            Award ID: RG/12/1/29262
            Funded by: The Centre of Excellence in Medical Engineering, funded by the Wellcome Trust and EPSRC
            Award ID: WT 088641/Z/09/Z
            Funded by: Department of Health, via the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust
            Full Paper
            Imaging Methodology—Full Papers
            Custom metadata
            May 2017
            Converter:WILEY_ML3GV2_TO_NLMPMC version:5.0.9 mode:remove_FC converted:02.05.2017

            Radiology & Imaging

            image navigators, nonrigid motion, coronary vessel wall, coronary mra


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