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      Practical considerations for delivering on the sustainability promise of fermentation-based biomanufacturing

      review-article
      Emerging Topics in Life Sciences
      Portland Press Ltd.
      biomanufacturing, biotechnology, fermentation, sustainability

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          Abstract

          Increasingly, bio-based products made via sugar-powered microbial cell factories and industrial fermentation are reaching the market and presenting themselves as sustainable alternatives to fossil and animal-based products. The sustainability potential of biotechnology, however, has been shown to come with trade-offs and cannot be taken for granted. Shared environmental impact hotspots have been identified across industrial fermentation-based products, including biomass production, energy consumption, and end-of-life fate. Based on both these patterns and our direct experience in preparing for the commercial-scale production of Brewed Protein™, we outline practical considerations for improving the sustainability performance of bio-based products made via industrial fermentation.

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          Most cited references20

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          Sustainable polymers from renewable resources

          Renewable resources are used increasingly in the production of polymers. In particular, monomers such as carbon dioxide, terpenes, vegetable oils and carbohydrates can be used as feedstocks for the manufacture of a variety of sustainable materials and products, including elastomers, plastics, hydrogels, flexible electronics, resins, engineering polymers and composites. Efficient catalysis is required to produce monomers, to facilitate selective polymerizations and to enable recycling or upcycling of waste materials. There are opportunities to use such sustainable polymers in both high-value areas and in basic applications such as packaging. Life-cycle assessment can be used to quantify the environmental benefits of sustainable polymers.
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            Carbon sequestration in agricultural soils via cultivation of cover crops – A meta-analysis

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              Eutrophication of aquatic ecosystems: bistability and soil phosphorus.

              Eutrophication (the overenrichment of aquatic ecosystems with nutrients leading to algal blooms and anoxic events) is a persistent condition of surface waters and a widespread environmental problem. Some lakes have recovered after sources of nutrients were reduced. In others, recycling of phosphorus from sediments enriched by years of high nutrient inputs causes lakes to remain eutrophic even after external inputs of phosphorus are decreased. Slow flux of phosphorus from overfertilized soils may be even more important for maintaining eutrophication of lakes in agricultural regions. This type of eutrophication is not reversible unless there are substantial changes in soil management. Technologies for rapidly reducing phosphorus content of overenriched soils, or reducing erosion rates, are needed to improve water quality.
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                Author and article information

                Journal
                Emerg Top Life Sci
                Emerg Top Life Sci
                ETLS
                Emerging Topics in Life Sciences
                Portland Press Ltd.
                2397-8554
                2397-8562
                12 November 2021
                8 September 2021
                : 5
                : 5 , Perspectives from life sciences industry
                : 711-715
                Affiliations
                Spiber Inc., Kakuganji, Mizukumi 234-1, Tsuruoka 179240, Japan
                Author notes
                Correspondence: David Lips ( david_lips@ 123456spiber.inc )
                Author information
                http://orcid.org/0000-0001-8679-1920
                Article
                ETLS-5-711
                10.1042/ETLS20210129
                8726053
                34495334
                a0900c48-4320-47c6-93b6-652b8edb22f8
                © 2021 The Author(s)

                This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).

                History
                : 24 June 2021
                : 18 August 2021
                : 24 August 2021
                Categories
                Biotechnology
                Synthetic Biology
                Computational Biology
                Perspective

                biomanufacturing,biotechnology,fermentation,sustainability

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