The research aimed to identify the crucial aspects of humanitarian organizations that can improve the effectiveness of disaster relief operations. The study involved 150 participants from Tanzanian humanitarian organizations and used a combination of quantitative and qualitative methods, including questionnaires and interviews. The researchers employed multiple regressions to examine the relationship between independent and dependent variables. The findings indicated that coordination among stakeholders and vertical logistics cooperation can enhance the effectiveness of disaster relief operations. The study concluded that the efficiency of humanitarian logistics is crucial for disaster relief operations and recommended that the government prioritize public-private partnerships, develop reliable infrastructure, and empower logistics service providers and humanitarian organizations. The study could guide policymakers in developing frameworks to improve cooperation among stakeholders and logistics systems in disaster relief operations. Additionally, it adds to the existing knowledge on stakeholder theory and strengthening the humanitarian logistics systems.