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      Biological Interactions of Carbon-Based Nanomaterials: From Coronation to Degradation

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          Abstract

          Carbon-based nanomaterials including single- and multi-walled carbon nanotubes, graphene oxide, fullerenes and nanodiamonds are potential candidates for various applications in medicine such as drug delivery and imaging. However, the successful translation of nanomaterials for biomedical applications is predicated on a detailed understanding of the biological interactions of these materials. Indeed, the potential impact of the so-called bio-corona of proteins, lipids, and other biomolecules on the fate of nanomaterials in the body should not be ignored. Enzymatic degradation of carbon-based nanomaterials by immune-competent cells serves as a special case of bio-corona interactions with important implications for the medical use of such nanomaterials. In the present review, we highlight emerging biomedical applications of carbon-based nanomaterials. We discuss recent studies on nanomaterial ‘coronation’ and how this impacts on biodistribution and targeting along with studies on the enzymatic degradation of carbon-based nanomaterials, and the role of surface modification of nanomaterials for these biological interactions.

          Graphical abstract

          The present review discusses biological interactions of carbon-based nanomaterials, focusing on bio-corona formation, biodegradation, and biodistribution and targeting for various biomedical applications.

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          Author and article information

          Journal
          101233142
          32817
          Nanomedicine
          Nanomedicine
          Nanomedicine : nanotechnology, biology, and medicine
          1549-9634
          1549-9642
          22 December 2015
          17 December 2015
          February 2016
          01 February 2017
          : 12
          : 2
          : 333-351
          Affiliations
          [a ]Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
          [b ]Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States
          [c ]National Institute of Nuclear Physics – INFN, 00044 Frascati, Province of Rome, Italy
          [d ]Department of Experimental Medicine and Surgery, University of Rome ‘Tor Vergata’, 00133 Rome, Italy
          [e ]Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, United States
          Author notes
          [* ]Correspondence: Institute of Environmental Medicine, Nobels väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden; Tel. +46 8 524 877 37; Fax: +46 8 34 38 49; bengt.fadeel@ 123456ki.se
          Article
          PMC4789123 PMC4789123 4789123 nihpa746055
          10.1016/j.nano.2015.11.011
          4789123
          26707820
          a0945b7d-0a5d-48ba-821e-61f8dc7f7b1f
          History
          Categories
          Article

          bio-corona,carbon nanotubes,graphene oxide,fullerenes,nanodiamonds,biodegradation

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