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      Significance of echocardiographic assessment for right ventricular function after balloon pulmonary angioplasty in patients with chronic thromboembolic induced pulmonary hypertension.

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          Abstract

          Balloon pulmonary angioplasty (BPA) may improve hemodynamics and exercise tolerance in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We studied consecutive 25 patients with CTEPH who underwent BPA and evaluated hemodynamics by right-sided heart catheterization. Right ventricular (RV) function was assessed before and after BPA by echocardiography including speckle-tracking echocardiography and 3-dimensional echocardiography. BPA improved the mean pulmonary artery pressure, pulmonary vascular resistance, and cardiac index. BPA also ameliorated the 3-dimentional RV volume, RV ejection fraction, and RV systolic peak strain, all of which were significantly correlated with hemodynamic parameters. The changes in cardiac index were significantly correlated with those in 3-dimentional RV volume index. Furthermore, RV dyssynchrony quantified by the RV strain analyses was ameliorated after BPA even in patients with mild pulmonary hypertension, implicating the merit of BPA in this patient population with CTEPH. BPA not only improved the hemodynamics in patients with CTEPH, but also ameliorated RV remodeling and dyssynchrony as assessed by 3-dimensional echocardiography or speckle-tracking echocardiography. Thus, the assessment of RV function may provide valuable information about the appropriate indication for BPA, its efficacy, and the therapeutic goal for patients with CTEPH.

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          Author and article information

          Journal
          Am. J. Cardiol.
          The American journal of cardiology
          1879-1913
          0002-9149
          Jan 15 2015
          : 115
          : 2
          Affiliations
          [1 ] Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan; Department of Cardiology, Hino Municipal Hospital, Tokyo, Japan.
          [2 ] Department of Laboratory Medicine, School of Medicine, Keio University, Tokyo, Japan. Electronic address: muratam@a7.keio.jp.
          [3 ] Department of Cardiology, School of Medicine, Keio University, Tokyo, Japan.
          [4 ] Department of Cardiology, Hino Municipal Hospital, Tokyo, Japan.
          Article
          S0002-9149(14)02022-0
          10.1016/j.amjcard.2014.10.034
          25476559
          a094a10c-5d92-42b0-af9d-0df49208c3c9
          Copyright © 2015 Elsevier Inc. All rights reserved.
          History

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