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      Long-term deprivation of oestrogens by ovariectomy potentiates beta-amyloid-induced working memory deficits in rats.

      British Journal of Pharmacology

      Rats, Wistar, Amyloid beta-Peptides, toxicity, Animals, Body Weight, drug effects, Estradiol, blood, Estrogens, deficiency, Female, Follicle Stimulating Hormone, Injections, Intraventricular, Maze Learning, Memory Disorders, chemically induced, physiopathology, Memory, Short-Term, Motor Activity, Ovariectomy, Peptide Fragments, Rats

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          Abstract

          1 In the present study, we examined whether deprivation of oestrogens by ovariectomy could modify learning and memory deficits caused by a continuous intracerebroventricular (i.c.v.) infusion of amyloid beta-peptide (Abeta), the major constituent of senile plaques in AD. 2 Neither long-term (3 months) nor short-term (1 month), deprivation of oestrogens by ovariectomy caused a significant impairment in spatial learning and memory in a water maze and spontaneous alternation behaviour in a Y-maze. 3 A continuous i.c.v. infusion of Abeta-(1-42) caused spatial learning and memory deficits in both ovariectomized and sham-operated rats. 4 The Abeta-induced working memory deficits were significantly potentiated in ovariectomized rats compared with sham-operated rats when mnemonic ability was examined 3 months after ovariectomy. 5 These results suggest that long-term deprivation of oestrogens induced by ovariectomy increases susceptibility to memory deficits produced by Abeta-(1-42) in rats.

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          Author and article information

          Journal
          10510453
          1571652
          10.1038/sj.bjp.0702811

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