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      Combining casein phosphopeptide-amorphous calcium phosphate with fluoride: synergistic remineralization potential of artificially demineralized enamel or not?

      1 , ,
      Journal of biomedical optics
      SPIE-Intl Soc Optical Eng

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          Abstract

          Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). The remineralizing potential of CPP-ACP per se, or when combined with 0.22% Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd laser beam at 441.5 nm with 18-mW power as an excitation source on a suitable setup based on a Spex 750-M monochromator provided with a photomultiplier tube (PMT) for detection of collected autofluorescence from sound enamel. Mesial surfaces are subjected to demineralization for ten days. The spectra from demineralized enamel are measured. Teeth are divided into three groups according to the remineralizing regimen: group 1 Recaldent per se, group 2 Recaldent combined with fluoride gel and ACP, and group 3 artificial saliva as a positive control. After following these protocols for three weeks, the spectra from the remineralized enamel are measured. The spectra of enamel autofluorescence are recorded and normalized to peak intensity at about 540 nm to compare spectra from sound, demineralized, and remineralized enamel surfaces. A slight red shift occurred in spectra from demineralized enamel, while a blue shift may occur in remineralized enamel. Group 2 shows the highest remineralizing potential. Combining fluoride and ACP with CPP-ACP can give a synergistic effect on enamel remineralization.

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          Author and article information

          Journal
          J Biomed Opt
          Journal of biomedical optics
          SPIE-Intl Soc Optical Eng
          1560-2281
          1083-3668
          September 4 2009
          : 14
          : 4
          Affiliations
          [1 ] Cairo University, Oral and Dental Medicine, Operative Dentistry, 11 El Saraya Street Manial, Cairo, 11451, Egypt. imsayad@gmail.com
          Article
          10.1117/1.3210780
          19725750
          a097fd55-9073-4ecf-bade-01c7c4c0708e

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