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Clinical assessment incorporating a personal genome.
Euan A Ashley
1 ,
Atul J Butte ,
Matthew T Wheeler ,
Rong Chen ,
Teri E Klein ,
Frederick E Dewey ,
Joel T Dudley ,
Kelly E Ormond ,
Aleksandra Pavlovic ,
Alexander A Morgan ,
Dmitry Pushkarev ,
Norma F Neff ,
Louanne Hudgins ,
Li Gong ,
Laura M Hodges ,
Dorit S Berlin ,
Caroline F Thorn ,
Katrin Sangkuhl ,
Joan M Hebert ,
Mark Woon ,
Hersh Sagreiya ,
Ryan Whaley ,
Joshua W Knowles ,
Michael F Chou ,
Joseph V Thakuria ,
Abraham M Rosenbaum ,
Alexander Wait Zaranek ,
George M Church ,
Henry T Greely ,
Stephen R Quake ,
Russ B Altman
May 01 2010
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Abstract
The cost of genomic information has fallen steeply, but the clinical translation of genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a complete human genome in a clinical context.