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      Facilitation of Vasopressin Release from the Neurohypophysis by Application of Electrical Stimuli in Bursts

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          Abstract

          The physiological significance of the ‘bursting’ pattern of firing exhibited by activated vasopressin-secreting neurones was investigated by delivering bursts of electrical stimuli to isolated rat neurohypophyses incubated in vitro and by determining vasopressin release. The stimuli were delivered in bursts at three different average frequencies (2.5, 5.0, and 7.5 Hz). For each average frequency, stimuli were delivered at a constant 10 Hz, and the durations of the burst and silence periods were altered, so that the stimulator was switched on for 25, 50 or 75% of the total time. The burst duration varied from 2.5 to 30 s. The vasopressin release generally increased with the average frequency of stimulation, but varied widely for different burst durations. The vasopressin release per stimulus pulse was found to correlate extremely well (r<sup>2</sup> = 0.91) with burst durations of up to 20 s, regardless of the average frequency. If it is assumed that complete recovery from the effects of each burst of stimuli took place during the intervening silence periods, it can be shown that vasopressin release per burst increased as the square of burst duration. By analogy with other neurosecretory systems, facilitation of calcium entry during the bursts may be responsible.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1984
          1984
          28 March 2008
          : 39
          : 4
          : 371-376
          Affiliations
          aDepartment of Anatomy, King’s College, London; bA.F.R.C. Institute of Animal Physiology, Cambridge; cDepartment of Anatomy, University of Cambridge, Cambridge, England
          Article
          124007 Neuroendocrinology 1984;39:371–376
          10.1159/000124007
          6493449
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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