Matrix Metalloproteinases: A Review

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Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

Hsin-Fang Yang-Yen, Jean-Claude Chambard, Yu-Lin Sun … (1990)

Glucocorticoids are potent inhibitors of collagenase induction by phorbol esters and inflammatory mediators. The target for this negative effect is the AP-1 site within the collagenase promoter, which also mediates its induction. Negative regulation is due to repression of AP-1 activity by the glucocorticoid receptor (GCR). While the GCR is a potent inhibitor of AP-1 activity (Jun/Fos), both c-Jun and c-Fos are potent repressors of GCR activity. In vitro experiments using purified GCR and c-Jun proteins suggest that mutual repression is due to direct interaction between the two. Direct interaction between GCR and either c-Jun or c-Fos is demonstrated by cross-linking and coimmunoprecipitation. These findings reveal a cross talk between two major signal transduction systems used to control gene transcription in response to extracellular stimuli, and a novel mechanism for transcriptional repression.

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Journal

Title: Critical Reviews in Oral Biology & Medicine

Abbreviated Title: Critical Reviews in Oral Biology & Medicine

Publisher: SAGE Publications

ISSN (Print): 1045-4411

ISSN (Electronic): 1544-1113

Publication date Created: January 1993

Publication date (Print): January 1993

Volume: 4

Issue: 2

Pages: 197-250

Article

DOI: 10.1177/10454411930040020401

PubMed ID: 8435466

SO-VID: a0b1235c-41a4-4438-beb6-9c6605b66bec

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