29
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Matrix Metalloproteinases: A Review

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Related collections

          Most cited references1

          • Record: found
          • Abstract: found
          • Article: not found

          Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

          Glucocorticoids are potent inhibitors of collagenase induction by phorbol esters and inflammatory mediators. The target for this negative effect is the AP-1 site within the collagenase promoter, which also mediates its induction. Negative regulation is due to repression of AP-1 activity by the glucocorticoid receptor (GCR). While the GCR is a potent inhibitor of AP-1 activity (Jun/Fos), both c-Jun and c-Fos are potent repressors of GCR activity. In vitro experiments using purified GCR and c-Jun proteins suggest that mutual repression is due to direct interaction between the two. Direct interaction between GCR and either c-Jun or c-Fos is demonstrated by cross-linking and coimmunoprecipitation. These findings reveal a cross talk between two major signal transduction systems used to control gene transcription in response to extracellular stimuli, and a novel mechanism for transcriptional repression.
            Bookmark

            Author and article information

            Journal
            Critical Reviews in Oral Biology & Medicine
            Critical Reviews in Oral Biology & Medicine
            SAGE Publications
            1045-4411
            1544-1113
            January 1993
            January 1993
            : 4
            : 2
            : 197-250
            Article
            10.1177/10454411930040020401
            8435466
            a0b1235c-41a4-4438-beb6-9c6605b66bec
            © 1993
            History

            Comments

            Comment on this article