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      Enhanced Functional Performance Characteristics of a New Polysulfone Membrane for High-Flux Hemodialysis

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          Elimination of uremic solutes with molecular weights up to 60 kD, without significant loss of albumin is an important therapeutic goal to optimize outcomes in chronic hemodialysis patients. To characterize a newly developed polysulfone dialyzer (APS-650) a comparative analysis was performed with a highly advanced polysulfone dialyzer (F-60S) including 22 stable chronic hemodialysis patients. Diffusive clearances were determined, and albumin loss was calculated. The elimination profile of uremic solutes up to 32.0 kD was assessed in vivo by sieving coefficients, clearances, and reduction ratios of β<sub>2</sub>-microglobulin (11.8 kD), myoglobin (17.2 kD), prolactin (23.0 kD), and α<sub>1</sub>-microglobulin (32.0 kD). Hemocompatibility was tested in serial measurements of total white blood cell count, platelet count, C3a, and neutrophil elastase. No significant albumin loss was detected. Significantly higher sieving coefficients, clearances, and reduction ratios for proteins with molecular weight up to 32.0 kD were demonstrated with the newly developed polysulfone membrane. Both polysulfone membranes were equal concerning hemocompatibility parameters. The APS-650 dialyzer allowed optimized hemodialysis treatment with respect to clearance of medium-sized uraemic solutes by high-flux dialysis.

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          Author and article information

          Blood Purif
          Blood Purification
          S. Karger AG
          12 August 2002
          : 20
          : 4
          : 325-333
          aApheresis Research Institute, Cologne, bBioArt Products, Rostock, cGerman Clinic for Diagnostics, Wiesbaden, d1st Department of Internal Medicine, University of Mainz, Germany
          63099 Blood Purif 2002;20:325–333
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 1, Tables: 5, References: 41, Pages: 9
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          Original Paper

          Cardiovascular Medicine, Nephrology

          Dialysis membrane, High-flux hemodialysis, Polysulfone


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