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Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders

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Headache: The Journal of Head and Face Pain

Wiley

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      Biological Insights From 108 Schizophrenia-Associated Genetic Loci

      Summary Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here, we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain providing biological plausibility for the findings. Many findings have the potential to provide entirely novel insights into aetiology, but associations at DRD2 and multiple genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that play important roles in immunity, providing support for the hypothesized link between the immune system and schizophrenia.
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        The International Classification of Headache Disorders, 3rd edition (beta version).

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          Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

          Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
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            Author and article information

            Affiliations
            [1 ]Genomics Research Centre, School of Biomedical Sciences; Institute of Health and Biomedical Innovation, QUT; Musk Ave Kelvin Grove QLD 4059 Australia
            Journal
            Headache: The Journal of Head and Face Pain
            Headache: The Journal of Head and Face Pain
            Wiley
            00178748
            April 2017
            April 2017
            March 08 2017
            : 57
            : 4
            : 537-569
            10.1111/head.13053
            © 2017

            http://doi.wiley.com/10.1002/tdm_license_1

            http://onlinelibrary.wiley.com/termsAndConditions

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