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      Prognostic value of lymphocyte/monocyte ratio in advanced Hodgkin lymphoma: correlation with International Prognostic Score and tumor associated macrophages.

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          Abstract

          We studied the prognostic significance of the absolute lymphocyte/monocyte count ratio (ALC/AMC), its contribution to the prognostic value of the International Prognostic Score (IPS), and evaluated if ALC/AMC could serve as a proxy for the frequency of CD68 + tumor-associated macrophages (TAMs) in 101 patients with advanced Hodgkin lymphoma (HL). The receiver operating characteristic (ROC) curve identified best cut-off values of 2.0 for ALC/AMC and 25% for CD68 + TAM. Patients with ALC/AMC < 2, IPS > 2 and > 25% CD68 + TAM had an inferior overall survival (OS) and event-free survival (EFS). Spearman's test also uncovered a significant correlation between the ALC/AMC and TAM. Multivariate analysis identified ALC/AMC < 2, IPS > 2 and > 25% CD68 + TAM as poor prognostic factors of OS and EFS. After evaluating ALC/AMC and IPS, we stratified patients into three progressively-worse-outcome groups (low-risk: 0 risk factors; intermediate: 1 risk factor; high: 2 risk factors). Our study encourages the combination of ALC/AMC with IPS, for refining risk prediction in advanced HL patients.

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          Author and article information

          Journal
          Leuk. Lymphoma
          Leukemia & lymphoma
          Informa UK Limited
          1029-2403
          1026-8022
          Aug 2016
          : 57
          : 8
          Affiliations
          [1 ] a Clinic of Hematology, Clinical Center of Serbia , Serbia ;
          [2 ] b Faculty of Medicine, University of Belgrade , Serbia ;
          [3 ] c Department of Histopathology , Clinical Center of Serbia , Serbia ;
          [4 ] d Institute of Medical statistics and Informatics, Faculty of Medicine University of Belgrade , Serbia ;
          [5 ] e Institute of Histology and Embryology, Faculty of Medicine University of Belgrade , Serbia.
          Article
          10.3109/10428194.2015.1110745
          26727349
          a0fcc968-32b6-4592-b14e-92b4fe295d81
          History

          IPS,Advanced Hodgkin lymphoma,ALC/AMC,TAM
          IPS, Advanced Hodgkin lymphoma, ALC/AMC, TAM

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