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      A synaptic model of memory: long-term potentiation in the hippocampus.

      Nature

      physiology, Synapses, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Models, Neurological, Memory, Hippocampus, Evoked Potentials, Electrophysiology, Calcium, Animals

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          Abstract

          Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.

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          Journal
          8421494
          10.1038/361031a0

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