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      Morphological Changes in the Optic Nerve after Chronic Exposure of Neonatal Rats to Cocaine and Amphetamine

      a , a , b

      Ophthalmic Research

      S. Karger AG

      Optic nerve, Cocaine, Amphetamine, Morphometry

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          Abstract

          We determined the effects of cocaine hydrochloride (15 mg/kg body weight/day) or amphetamine sulfate (25 mg/kg body weight/day) on the optic nerve in groups of rats exposed from postnatal day 1 to 30. Qualitative and quantitative studies of cross-sections of the optic nerves showed different patterns of organization, namely the presence of degenerative features in drug-treated animals and significant differences in the proportion of the nerve occupied by glial cells and their processes and nerve fiber bundles. No significant differences of the total number of fibers were found. Taken together, these data indicate that the optic nerve is vulnerable to early exposure to cocaine and amphetamine which cause developmental changes in this link of the visual pathways.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1991
          1991
          10 December 2009
          : 23
          : 6
          : 295-302
          Affiliations
          aDepartment of Ophthalmology and bInstitute of Anatomy, Medical School of Porto, Portugal
          Article
          267126 Ophthalmic Res 1991;23:295–302
          10.1159/000267126
          1803311
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Paper

          Vision sciences, Ophthalmology & Optometry, Pathology

          Morphometry, Optic nerve, Cocaine, Amphetamine

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