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      CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases

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          Abstract

          CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. In this review, we will focus on how CD146 and sCD146 contribute to the pathogenesis of the aforementioned autoimmune diseases and discuss the relevance of considering it as a biomarker in these pathologies.

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                Author and article information

                Journal
                Biomedicines
                Biomedicines
                biomedicines
                Biomedicines
                MDPI
                2227-9059
                10 December 2020
                December 2020
                : 8
                : 12
                : 592
                Affiliations
                [1 ]Hematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, France; ahmadjoshkon@ 123456hotmail.com (A.J.); Julien.bermudez@ 123456ap-hm.fr (J.B.); richard.bachelier@ 123456inserm.fr (R.B.); cldubrou@ 123456gmail.com (C.D.); Alexandrine.bertaud@ 123456univ-amu.fr (A.F.-B.); Aurelie.leroyer@ 123456univ-amu.fr (A.S.L.); Francoise.dignat-george@ 123456univ-amu.fr (F.D.-G.); marcel.blot-chabaud@ 123456laposte.net (M.B.-C.); Nathalie.bardin@ 123456univ-amu.fr (N.B.)
                [2 ]Service d’immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique Hôpitaux de Marseille (AP-HM), 13005 Marseille, France; jose.boucraut@ 123456univ-amu.fr
                [3 ]Pulmonology Department and Lung Transplant Team, North Hospital, Assistance Publique Hôpitaux de Marseille (AP-HM), 13015 Marseille, France
                [4 ]Timone Neuroscience Institute, UMR CNRS 7289, Aix-Marseille University, 13005 Marseille, France
                [5 ]Hematology and Vascular Biology Department, Hopital de la Conception, Assistance Publique Hôpitaux de Marseille (AP-HM), 13005 Marseille, France
                Author notes
                Author information
                https://orcid.org/0000-0002-9459-4318
                https://orcid.org/0000-0001-8823-0959
                https://orcid.org/0000-0001-8585-5275
                Article
                biomedicines-08-00592
                10.3390/biomedicines8120592
                7764286
                33321883
                a130916c-8b44-40f3-9dcb-5589a12e6158
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 October 2020
                : 04 December 2020
                Categories
                Review

                cd146,soluble cd146,inflammation angiogenesis,autoimmunity

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