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      Soft Tissue Sarcoma Stiffness and Perfusion Evaluation by MRE and DCE-MRI for Radiation Therapy Response Assessment: A Technical Feasibility Study

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          Abstract

          Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.

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          Author and article information

          Journal
          101675002
          44801
          Biomed Phys Eng Express
          Biomed Phys Eng Express
          Biomedical physics & engineering express
          2057-1976
          14 February 2020
          22 May 2019
          July 2019
          01 July 2020
          : 5
          : 4
          Affiliations
          [1 ]Department of Radiation Oncology, Mayo Clinic, 200 1 st Street SW, Rochester, MN 55905
          [2 ]Department of Radiology, Mayo Clinic, 200 1 st Street SW, Rochester, MN 55905
          [3 ]Mayo Clinic Graduate School of Biomedical Sciences, 200 1 st Street SW, Rochester, MN 55905
          [4 ]Department of Pathology, Mayo Clinic, 200 1 st Street SW, Rochester, MN 55905
          [5 ]Department of Oncology, Mayo Clinic, 200 1 st St SW, Rochester MN, 55905
          Article
          PMC7045581 PMC7045581 7045581 nihpa1555142
          10.1088/2057-1976/ab2175
          7045581
          32110433
          Categories
          Article

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