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      Are serum gamma-glutamyl transferase, high-sensitivity C-reactive protein, and ischaemia-modified albumin useful in diagnosing PCOS?

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          Abstract

          We assessed the serum levels of gamma-glutamyl transferase (GGT), high-sensitivity C-reactive protein (hsCRP) and ischaemia-modified albumin (IMA) in patients with polycystic ovary syndrome (PCOS). Fifty-three patients with PCOS were included in our study along with 40 women with no PCOS as the control group. The patients were divided according to their body mass index (BMI). GGT levels were significantly higher in the women with PCOS than the women in the control group (p < 0.05). They were also significantly higher in the PCOS women who were normoweight and overweight than the normoweight and overweight women in the control group (p < 0.001). There was no significant difference in the circulating levels of hsCRP and IMA between the women with PCOS and the controls or between the normoweight and overweight subgroups. GGT may be associated with the diagnosis of PCOS when the threshold is set at >15.5 U/L. With the application of this threshold, raised GGT levels had 83% sensitivity (95% CI 0.70-0.90) and 67.5% specificity (95% CI 0.52-0.79), for the diagnosis of PCOS. In our study, GGT levels were elevated in the PCOS patients independent of BMI and could thus be an important marker of PCOS.

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          Author and article information

          Journal
          J Obstet Gynaecol
          Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
          Informa UK Limited
          1364-6893
          0144-3615
          Oct 2016
          : 36
          : 7
          Affiliations
          [1 ] a Department of Obstetrics and Gynecology , Etimesgut Military Hospital , Ankara , Turkey.
          [2 ] b Department of Obstetrics and Gynecology , Gulhane Military Medical Academy , Ankara , Turkey.
          [3 ] c Department of Biochemistry , Gulhane Military Medical Academy , Ankara , Turkey.
          Article
          10.1080/01443615.2016.1174827
          27183992
          a136ebde-5126-438e-a6f6-4d55c6e57021
          History

          Body mass index,PCOS,gamma-glutamyl transferase,high-sensitivity C-reactive protein,ischaemia-modified albumin

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