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      Rapid evolution of RNA genomes.

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          Abstract

          RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication. This high mutation frequency is coupled with high rates of replication reflected in rates of RNA genome evolution which can be more than a millionfold greater than the rates of the DNA chromosome evolution of their hosts. There are some disease implications for the DNA-based biosphere of this rapidly evolving RNA biosphere.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Mar 26 1982
          : 215
          : 4540
          Article
          10.1126/science.7041255
          7041255
          a1377c2e-8356-41bd-8b1e-c33e1832fe30
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