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      Cell Adhesion on Polycaprolactone Modified by Plasma Treatment

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          Abstract

          We have investigated the influence of various plasma treatments of electrospun polycaprolactone (PCL) scaffolds on the adhesion and proliferation of human umbilical endothelial cells (HUVEC). The PCL scaffolds were treated in plasmas created in O 2, NH 3or SO 2gas at identical conditions. Surface functionalization of plasma-treated samples was determined using X-ray photoelectron spectroscopy. Cell adhesion and morphology were investigated by scanning electron microscopy and the influence of plasma treatment on cell adhesion and viability was evaluated with cell viability assay (MTT assay). The results showed the highest metabolic activity of HUVEC on PCL samples treated with O 2and NH 3plasma. Accordingly, the cells reflected the best adhesion and morphology on O 2and NH 3plasma-treated PCL samples already at 3 h. Moreover, treatment with O 2and NH 3plasma even stimulated endothelial cell proliferation on PCL surfaces by 60% as measured at 24 h, showing significant improvement in endothelialization of this material. Contrarily, SO 2plasma appeared to be less promising in comparison with O 2and NH 3plasma; however, it was still better than without any plasma treatment. Thus, our results importantly contribute to the biocompatibility improvement of the PCL polymer, commonly used for scaffolds in tissue engineering.

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          Plasma Methods for the Generation of Chemically Reactive Surfaces for Biomolecule Immobilization and Cell Colonization - A Review

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            Properties and medical applications of polylactic acid: A review

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              Plasma Surface Modification of Biodegradable Polymers: A Review

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                Author and article information

                Journal
                International Journal of Polymer Science
                International Journal of Polymer Science
                Hindawi Limited
                1687-9422
                1687-9430
                2016
                2016
                : 2016
                :
                : 1-9
                Article
                10.1155/2016/7354396
                a13acb3a-90b1-4cc4-a1c2-9e9cac65d93c
                © 2016

                http://creativecommons.org/licenses/by/4.0/

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