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      Superoxide Dismutase Molecules in Human Cataractous Lenses

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          Abstract

          Specific activity of superoxide dismutase (SOD) in cataractous lenses was examined. Immunoprecipitation with monospecific antibodies showed an accumulation of catalytically inactive, but antigenically reactive enzyme molecules in lenses with various types of cataracts. The inactive enzyme molecules can be demonstrated in all kinds of cataracts, including dense, mature cataracts with very low or nondetectable enzyme activity. In cataracts from diabetic patients, the mean enzyme activity was higher than in nondiabetic patients. This was especially marked in nuclear cataracts, in which the specific activity of SOD was higher than in similar cataracts from nondiabetics.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1986
          1986
          04 December 2009
          : 18
          : 6
          : 332-337
          Affiliations
          aDepartment of Ophthalmology, Rambam Medical Center and Faculty of Medicine, Technion; bDepartment of Biology, Technion-Israel Institute of Technology, Haifa, Israel
          Article
          265459 Ophthalmic Res 1986;18:332–337
          10.1159/000265459
          3299197
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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