+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Ultrastructural Changes Associated with the Induction and Reversal of a Chemically Induced Cataract

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Intraocular chemical injury results in extensive cytopathological changes in the retropupillary region of the lens. The epithelial cells exhibit cytolysis and superficial fibers are damaged. Cellular debris is also noted throughout the innermost aspect of an otherwise intact capsule. The injured region is repopulated by cells which migrate into the wound focus to form a multilayered epithelium. Lysis of the damaged capsular regions, in addition to phagocytolysosomal activity by the incoming epithelial cells, appears to play a major role in the restoration of capsule morphology and in the normalization of the epithelial monolayer and the cortical fibers. Autolysosomes and/or cytolysosomes detected in the multilayered epithelium are prime candidates for the removal of tissue debris from the injured lens. Reversal of the retropupillary opacity coincides with the restoration of lens cytoarchitecture.

          Related collections

          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 9
          : 5
          : 296-307
          Department of Biological Sciences, Oakland University, Rochester, Mich, and Department of Anatomy, Wayne State University School of Medicine, Detroit, Mich.
          264898 Ophthalmic Res 1977;9:296–307
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12


          Comment on this article