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      Ultrastructural Changes Associated with the Induction and Reversal of a Chemically Induced Cataract

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          Abstract

          Intraocular chemical injury results in extensive cytopathological changes in the retropupillary region of the lens. The epithelial cells exhibit cytolysis and superficial fibers are damaged. Cellular debris is also noted throughout the innermost aspect of an otherwise intact capsule. The injured region is repopulated by cells which migrate into the wound focus to form a multilayered epithelium. Lysis of the damaged capsular regions, in addition to phagocytolysosomal activity by the incoming epithelial cells, appears to play a major role in the restoration of capsule morphology and in the normalization of the epithelial monolayer and the cortical fibers. Autolysosomes and/or cytolysosomes detected in the multilayered epithelium are prime candidates for the removal of tissue debris from the injured lens. Reversal of the retropupillary opacity coincides with the restoration of lens cytoarchitecture.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1977
          1977
          03 December 2009
          : 9
          : 5
          : 296-307
          Affiliations
          Department of Biological Sciences, Oakland University, Rochester, Mich, and Department of Anatomy, Wayne State University School of Medicine, Detroit, Mich.
          Article
          264898 Ophthalmic Res 1977;9:296–307
          10.1159/000264898
          a13f25c1-6efb-4d23-bd50-0fb5fdc083c2
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 09 August 1977
          : 05 October 1977
          Page count
          Pages: 12
          Categories
          Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Wound healing,Secondary lysosomes,Hyperplasia,Reversible opacity,Electron microscopy,Chemical injury,Rabbit lens

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