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      Biochemical Gradients to Generate 3D Heterotypic‐Like Tissues with Isotropic and Anisotropic Architectures

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          Most cited references 47

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          Fiji: an open-source platform for biological-image analysis.

          Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis. Fiji uses modern software engineering practices to combine powerful software libraries with a broad range of scripting languages to enable rapid prototyping of image-processing algorithms. Fiji facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system. We propose Fiji as a platform for productive collaboration between computer science and biology research communities.
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            NIH Image to ImageJ: 25 years of image analysis

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              Remodelling the extracellular matrix in development and disease.

              The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative changes in the ECM, mediated by specific enzymes that are responsible for ECM degradation, such as metalloproteinases. The ECM interacts with cells to regulate diverse functions, including proliferation, migration and differentiation. ECM remodelling is crucial for regulating the morphogenesis of the intestine and lungs, as well as of the mammary and submandibular glands. Dysregulation of ECM composition, structure, stiffness and abundance contributes to several pathological conditions, such as fibrosis and invasive cancer. A better understanding of how the ECM regulates organ structure and function and of how ECM remodelling affects disease progression will contribute to the development of new therapeutics.
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                Author and article information

                Journal
                Advanced Functional Materials
                Adv. Funct. Mater.
                Wiley
                1616-301X
                1616-3028
                October 10 2018
                November 2018
                October 09 2018
                November 2018
                : 28
                : 48
                : 1804148
                Affiliations
                [1 ]3B's Research GroupI3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAvePark, Parque de Ciência e TecnologiaZona Industrial da Gandra 4805‐017 Barco Guimarães Portugal
                [2 ]ICVS/3B's—PT Government Associate Laboratory 4806‐909 Braga/Guimarães Portugal
                [3 ]Bio‐Acoustic MEMS in Medicine (BAMM) LaboratoryCanary Center at Stanford for Cancer Early DetectionDepartment of RadiologyStanford School of Medicine Palo Alto CA 94304 USA
                [4 ]The Discoveries Centre for Regenerative and Precision MedicineHeadquarters at University of Minho Avepark 4805‐017 Barco Guimarães Portugal
                [5 ]Electrical Engineering DepartmentStanford University Stanford CA 94305 USA
                Article
                10.1002/adfm.201804148
                © 2018

                http://onlinelibrary.wiley.com/termsAndConditions#am

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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