Alkenes with antioxidative activities from Murraya koenigii (L.) Spreng.

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Abstract

Four new alkenes (1-4), and six known alkenes (5-12) were isolated from Murraya koenigii (L.) Spreng. Their structures were elucidated on the basis of spectroscopic analyses and references. Compounds (1-12) were evaluated for antioxidative activities. Among them, compounds 1, 2, 4, and 7 exhibited significant antioxidative activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with IC50=21.4-49.5 μM. The known compounds (5-12) were isolated from this plant for the first time.

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Author and article information

Journal

Journal ID (iso-abbrev): Bioorg. Med. Chem. Lett.

Title: Bioorganic & medicinal chemistry letters

Publisher: Elsevier BV

ISSN (Electronic): 1464-3405

ISSN (Print): 0960-894X

Publication date (Electronic): Feb 01 2016

Volume: 26

Issue: 3

Affiliations

[1 ] Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China. Electronic address: maqinge2006@163.com.

[2 ] Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.

[3 ] Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

[4 ] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Article

Publisher Item ID: S0960-894X(15)30403-0

DOI: 10.1016/j.bmcl.2015.12.091

PubMed ID: 26777629

SO-VID: a14e5053-ac48-4482-a357-dbe639099edd

History

Keywords: Alkene,Antioxidative activity,Murraya koenigii

Data availability:

Keywords: Alkene, Antioxidative activity, Murraya koenigii

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