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      Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.

      Chemical & pharmaceutical bulletin

      pharmacology, chemistry, isolation & purification, Fruit, Garcinia mangostana, Anti-Bacterial Agents, Microbial Sensitivity Tests, Protein Prenylation, Xanthones

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          Abstract

          Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.

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          12843596

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