Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Deranged Fat Metabolism and the Lowering Effect of Carbohydrate-Poor Diet on Serum Triglycerides in Patients with Chronic Renal Failure

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Serum lipids were studied in 98 nonnephrotic patients with chronic renal failure at pre-dialysis, dialysis and post-transplant stages. Hypertriglyceridemia was observed in pre-dialysis patients, although its degree was a modest one as compared to the preceding occidental reports. This difference may be ascribed to an ethnic peculiarity, since Japanese patients have a diet richer in carbohydrate than their Caucasian counterparts (% carbohydrate/total calories of 70 vs. 54–58). Hypertriglyceridemia persisted in the hemodialysis group, while no elevation was observed in serum cholesterol level. Elevated serum cholesterol levels were found in post-transplant patients. 8 pre-dialysis patients were fed carbohydrate-rich (64% of total calories) and carbohydrate-poor (47%) diets, each for 1 week successively, while maintaining an isocaloric level of 1,800 cal and a similar polyunsaturated to saturated fatty acid ratio (0.90 vs. 0.76). Significant reduction in serum triglycerides (TG) took place due to a decrease in dietary carbohydrate, while the plasma extrahepatic and hepatic post-heparinic lipolytic activities (PHLAs) showed constant decreased levels throughout the diet therapy. This may be suggestive of a deranged TG metabolism present in all pre-dialysis patients studied, primarily because all the pre-diet PHLAs were low even though the serum TG levels were not necessarily elevated and secondarily, a carbohydrate-rich diet could not induce such a reactive elevation in extrahepatic PHLA as would normally be observed. In conclusion, hypertriglyceridemia in patients with chronic renal failure may be caused by potentially defective TG-clearing ability that becomes manifest by conventional carbohydrate-rich diet.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1980
          1980
          02 December 2008
          : 25
          : 1
          : 8-14
          Affiliations
          Department of Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa-ken; Department of Medicine, Keio University School of Medicine, Tokyo, and Department of Medicine, Jikei-kai Medical School, Tokyo
          Article
          181746 Nephron 1980;25:8–14
          10.1159/000181746
          6986038
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

          Comments

          Comment on this article