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      Effect of Cyproterone Acetate Acutely Administered on the Pituitary-Testicular Axis

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          The effect of cyproterone acetate (CA) on the pituitary-testicular axis was studied in 6 healthy men. A dose of 300 mg of CA was administered orally in the early morning, after 3 h blood samples were collected using a multiple sample technique. Testosterone (T) levels were decreased by CA in all subjects (p 0.01), LH in all (p < 0.01) but one whereas 17-hydroxyprogesterone did not show any significant variation. In vitro, using an equilibrium dialysis, CA displaced T from plasma-binding proteins in males at 37 °C. The role of testosterone-binding globulin on the effects of CA on the pituitary-testicular axis remains to be clarified.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 11
          : 3
          : 109-114
          Andrology Center, Department of Medicine, Catania Medical School, University of Catania, Ospedale Garibaldi, Catania
          179046 Horm Res 1979;11:109–114
          © 1979 S. Karger AG, Basel

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          Pages: 6
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