Altered calcium dynamics do not account for attenuation of endothelium-derived hyperpolarizing factor-mediated dilations in the female middle cerebral artery.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The contribution of endothelium-derived hyperpolarizing factor (EDHF) to ATP-mediated dilations is significantly attenuated in the rat middle cerebral artery of intact and estrogen-treated ovariectomized (OVX) females compared with males and vehicle-treated OVX females. Since an increase in endothelial calcium appears to be a critical prerequisite in the EDHF response, we tested the hypothesis that endothelial cell intracellular calcium ([Ca(2+)](i)) fails to reach sufficient levels to elicit robust EDHF-mediated dilations in females and that this effect is mediated by estrogen.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Stroke

Title: Stroke

ISSN (Electronic): 1524-4628

ISSN (Print): 0039-2499

Publication date (Electronic): Dec 2002

Volume: 33

Issue: 12

Affiliations

[1 ] Department of Anesthesiology, Baylor College of Medicine, Houston, Texas, USA. egolding@bcm.tmc.edu

Article

DOI: 10.1161/01.STR.0000035907.82204.39

PubMed ID: 12468799

SO-VID: a18d598b-21b6-40f1-b2bc-9fc0a02a5b0f

History

Data availability:

Comments

Comment on this article

scite_

Cited by 3

See all cited by