Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model.

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Abstract

Stress evokes lipolytic release of free fatty acid (FFA) and low-grade inflammation in visceral adipose tissue, mediated by increased adipokine secretion, and contributes to glucose metabolism disorder and prothrombotic state. We tested the hypothesis that alogliptin, a dipeptidyl peptidase-4 inhibitor, can ameliorate the biological effects of chronic stress in mice.

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Journal

Journal ID (iso-abbrev): Psychoneuroendocrinology

Title: Psychoneuroendocrinology

Publisher: Elsevier BV

ISSN (Electronic): 1873-3360

ISSN (Print): 0306-4530

Publication date (Electronic): Nov 2016

Volume: 73

Affiliations

[1 ] Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

[2 ] Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan. Electronic address: kyousuke@med.nagoya-u.ac.jp.

[3 ] Department of Blood Transfusion, Nagoya University Hospital, Nagoya, Japan.

[4 ] Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan.

[5 ] Department of Blood Transfusion, Aichi Medical University Hospital, Nagakute, Japan.

[6 ] Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan; Department of Blood Transfusion, Nagoya University Hospital, Nagoya, Japan.

[7 ] Department of Pathology, Nagoya University Hospital, Nagoya, Japan.

Article

Publisher Item ID: S0306-4530(16)30519-4

DOI: 10.1016/j.psyneuen.2016.08.004

PubMed ID: 27509090

SO-VID: a1bc6a09-6c72-46b4-aa99-7574886b237d

History

Keywords: Restraint stress,Reactive oxygen species,DPP-4 Inhibitor,Insulin resistance,Adipose tissue inflammation

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Keywords: Restraint stress, Reactive oxygen species, DPP-4 Inhibitor, Insulin resistance, Adipose tissue inflammation

Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model.

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Karger: Nutrition and Dietetics

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