Effect of cinnamaldehyde on Cav-1 and Survivin expression in epilepsy

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background:

This systematic review aims to assess the effect of cinnamaldehyde on Cav-1 and Survivin expression in epilepsy.

Methods:

We will search Cochrane Library, PUBMED, EMBASE, CINAHL, Web of Science, Google Scholar, PsycINFO, WANGFANG, VIP, CBM, and CNKI from their inceptions to the March 31, 2020, without language restrictions. Two authors will independently carry out searching literature records, scanning titles and abstracts, full texts, collecting data, and assessing risk of bias. RevMan 5.3 software will be used for statistical analysis.

Results:

This systematic review will investigate whether cinnamaldehyde is effective on Cav-1 and Survivin expression in epilepsy.

Conclusion:

Its findings will provide helpful evidence for the effect of cinnamaldehyde on Cav-1 and Survivin expression in epilepsy.

Systematic review registration: INPLASY202040152.

Related collections

Most cited references 21

Record: found
Abstract: found
Article: found

Is Open Access

Incidence, Recurrence, and Risk Factors for Peri-ictal Central Apnea and Sudden Unexpected Death in Epilepsy

Laura Castells Vilella, Nuria Lacuey, Johnson P. Hampson … (2019)

Introduction: Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e., post-ictal generalized EEG suppression (PGES) and recurrence. Methods: Prospective, multi-center seizure monitoring study of autonomic, and breathing biomarkers of SUDEP in adults with intractable epilepsy and monitored seizures. Video EEG, thoraco-abdominal excursions, capillary oxygen saturation, and electrocardiography were analyzed. A subgroup analysis determined the incidences of recurrent ICA and PCCA in patients with ≥2 recorded seizures. We excluded status epilepticus and obscured/unavailable video. Central apnea (absence of thoracic-abdominal breathing movements) was defined as ≥1 missed breath, and ≥5 s. ICA referred to apnea preceding or occurring along with non-convulsive seizures (NCS) or apnea before generalized convulsive seizures (GCS). Results: We analyzed 558 seizures in 218 patients (130 female); 321 seizures were NCS and 237 were GCS. ICA occurred in 180/487 (36.9%) seizures in 83/192 (43.2%) patients, all with focal epilepsy. Sleep state was related to presence of ICA [RR 1.33, CI 95% (1.08–1.64), p = 0.008] whereas extratemporal epilepsy was related to lower incidence of ICA [RR 0.58, CI 95% (0.37–0.90), p = 0.015]. ICA recurred in 45/60 (75%) patients. PCCA occurred in 41/228 (18%) of GCS in 30/134 (22.4%) patients, regardless of epilepsy type. Female sex [RR 11.30, CI 95% (4.50–28.34), p < 0.001] and ICA duration [RR 1.14 CI 95% (1.05–1.25), p = 0.001] were related to PCCA presence, whereas absence of PGES was related to absence of PCCA [0.27, CI 95% (0.16–0.47), p < 0.001]. PCCA duration was longer in males [HR 1.84, CI 95% (1.06–3.19), p = 0.003]. In 9/17 (52.9%) patients, PCCA was recurrent. Conclusion: ICA incidence is almost twice the incidence of PCCA and is only seen in focal epilepsies, as opposed to PCCA, suggesting different pathophysiologies. ICA is likely to be a recurrent semiological phenomenon of cortical seizure discharge, whereas PCCA may be a reflection of brainstem dysfunction after GCS. Prolonged ICA or PCCA may, respectively, contribute to SUDEP, as evidenced by two cases we report. Further prospective cohort studies are needed to validate these hypotheses.

0 comments Cited 37 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Prevalence and risk factors of depression and anxiety among patients with convulsive epilepsy in rural West China

Hai-Jiao Wang, Ge Tan, Ying Deng … (2018)

To explore the prevalence and risk factors of depression and anxiety in patients with convulsive epilepsy (PWE) in rural West China.

0 comments Cited 23 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial

Nicholas M. Barbaro, Mark Quigg, Mariann Ward … (2018)

0 comments Cited 18 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Medicine (Baltimore)

Journal ID (iso-abbrev): Medicine (Baltimore)

Journal ID (publisher-id): MEDI

Title: Medicine

Publisher: Wolters Kluwer Health

ISSN (Print): 0025-7974

ISSN (Electronic): 1536-5964

Publication date Collection: 05 June 2020

Publication date (Electronic): 05 June 2020

Volume: 99

Issue: 23

Electronic Location Identifier: e20459

Affiliations

[a ]Third Ward of Neurology Department

[b ]Department of Critical Medicine

[c ]Fourth Ward of Neurology Department

[d ]Second Ward of Gastroenterology Department

[e ]First Ward of Neurology Department, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Author notes

[∗ ]Correspondence: Xin Li, First Ward of Neurology Department, First Affiliated Hospital of Jiamusi University, No.348 Dexiang Street, Xiangyang District, Jiamusi 154002, China (e-mail: xinli196811@ 123456yeah.net)

Article

Publisher ID: MD-D-18-03826 Accession ID: 20459

DOI: 10.1097/MD.0000000000020459

PMC ID: 7306385

PubMed ID: 32501993

SO-VID: a1c23337-f408-4a2d-8575-72ed488c7a6f

License:

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

History

Date received : 25 April 2020

Date accepted : 28 April 2020

Funding

Funded by: Scientific Research Project of Heilongjiang Provincial Department of Health

Award ID: 2018143

Award Recipient : Not Applicable

Custom metadata

OPEN-ACCESS TRUE

Keywords: cav-1,cinnamaldehyde,effect,epilepsy,survivin

Data availability:

Keywords: cav-1, cinnamaldehyde, effect, epilepsy, survivin

Effect of cinnamaldehyde on Cav-1 and Survivin expression in epilepsy : A protocol of systematic review and meta-analysis

Read this article at

Abstract

Background:

Methods:

Results:

Conclusion:

Related collections

Hogrefe Medicine

Most cited references 21

Incidence, Recurrence, and Risk Factors for Peri-ictal Central Apnea and Sudden Unexpected Death in Epilepsy

Prevalence and risk factors of depression and anxiety among patients with convulsive epilepsy in rural West China

Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial

Author and article information

Journal

Affiliations

Author notes

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 901

Cited by 1

Most referenced authors 963