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      Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.

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          Abstract

          The β-receptor antagonist carvedilol blocks a range of ion channels. K2P 2.1 (TREK1) and K2P 10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first objective was to investigate acute effects of carvedilol on human K2P 2.1 and K2P 10.1 channels. Second, we sought to study ATI-dependent modulation of K2P K(+) current sensitivity to carvedilol.

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          Author and article information

          Journal
          Br J Pharmacol
          British journal of pharmacology
          Wiley
          1476-5381
          0007-1188
          Dec 2014
          : 171
          : 23
          Affiliations
          [1 ] Department of Cardiology, Medical University Hospital, Heidelberg, Germany.
          Article
          10.1111/bph.12596
          4294033
          25168769
          a1cd7510-0a86-46db-9bab-d9cfe501b5ec
          © 2014 The British Pharmacological Society.
          History

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