Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study

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Abstract

How to cite this article: Sharma A. Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study. Indian J Crit Care Med 2021;25(1):6–7.

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Management of opioid analgesic overdose.

Edward Boyer (2012)

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Drug induced QT prolongation and torsades de pointes.

Wendy Y. Yap, John Camm (2003)

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Is Open Access

Opioids and Cardiac Arrhythmia: A Literature Review

Mina Behzadi, Siyavash Joukar, Ahmad Beik (2018)

Objective: One of the most important side effects of opioids is their influence on the electrical activity of the heart. This review focusses on the effects of opioids on QT interval prolongation and their arrhythmogenic liability. Methods: By using various keywords, papers published up to 2018 in different databases were searched and identified. The search terms were opioids names, corrected QT interval, human-ether-a-go-go gene, torsades de pointes (TdP), cardiac arrhythmias, opioid dependence and other relevant terms. It emphasized the effects of each opioid agent alone on electrocardiogram (ECG) and some interactions. Results: Available data indicate that some opioids such as methadone are high-risk even at low doses, and have potential for prolongation of the QT interval and development of TdP, a dangerous ventricular tachycardia. A number of opioids such as tramadol and oxycodone are intermediate risk drugs and may develop long QT interval and TdP in high doses. Some other opioids such as morphine and buprenorphine are low-risk drugs and do not produce QT interval prolongation and TdP at least in routine doses. Opium-consumers are at higher risk of supra-ventricular arrhythmias, sinus bradycardia, cardiac block and atrial fibrillation. Conclusion: The cardiac arrhythmogenicity of various opioids is different. Methadone has a higher capability to induce long QT interval and dangerous arrhythmias in conventional doses than others. To reduce of arrhythmogenic risk, high doses of opioids must be used cautiously with periodic monitoring of ECG in high-risk consumers such as patients under opioid maintenance treatment.

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Journal

Journal ID (nlm-ta): Indian J Crit Care Med

Journal ID (iso-abbrev): Indian J Crit Care Med

Journal ID (publisher-id): IJCCM

Title: Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine

Publisher: Jaypee Brothers Medical Publishers

ISSN (Print): 0972-5229

ISSN (Electronic): 1998-359X

Publication date (Print): January 2021

Volume: 25

Issue: 1

Pages: 6-7

Affiliations

[1]Department of Anesthesia and Intensive Care, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India

Author notes

Ankit Sharma, Department of Anesthesia and Intensive Care, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India, Phone: +91 9718592464, e-mail: ankitmd@ 123456gmail.com

Article

DOI: 10.5005/jp-journals-10071-23704

PMC ID: 7874287

PubMed ID: 33603292

SO-VID: a1cf8999-ca13-42d2-b8d0-83292eba481f

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© Jaypee Brothers Medical Publishers. 2021 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study

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Preventive and Emergency Medicine Insights

Most cited references 12

Management of opioid analgesic overdose.

Drug induced QT prolongation and torsades de pointes.

Opioids and Cardiac Arrhythmia: A Literature Review

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