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      TRP functions in the broncho-pulmonary system.

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          Abstract

          The current understanding of the role of transient receptor potential (TRP) channels in the airways and lung was initially based on the localization of a series of such channels in a subset of sensory nerve fibers of the respiratory tract. Soon after, TRP channel expression and function have been identified in respiratory nonneuronal cells. In these two locations, TRPs regulate physiological processes aimed at integrating different stimuli to maintain homeostasis and to react to harmful agents and tissue injury by building up inflammatory responses and repair processes. There is no doubt that TRPs localized in the sensory network contribute to airway neurogenic inflammation, and emerging evidence underlines the role of nonneuronal TRPs in orchestrating inflammation and repair in the respiratory tract. However, recent basic and clinical studies have offered clues regarding the contribution of neuronal and nonneuronal TRPs in the mechanism of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cough, and other respiratory diseases.

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          Author and article information

          Journal
          Semin Immunopathol
          Seminars in immunopathology
          Springer Nature
          1863-2300
          1863-2297
          May 2016
          : 38
          : 3
          Affiliations
          [1 ] Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy.
          [2 ] Chiesi Farmaceutici S.p.A, Parma, Italy.
          [3 ] Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
          [4 ] Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy. pierangelo.geppetti@unifi.it.
          Article
          10.1007/s00281-016-0557-1
          10.1007/s00281-016-0557-1
          27083925

          Neurogenic inflammation, Oxidative stress, TRPA1, TRPV1

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