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      Arrhythmogenic Mechanisms in Human Atrial and Ventricular Muscle Fibers

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          Abstract

          Mechanisms which may lead to cardiac arrhythmias were studied in atrial and ventricular tissues from human hearts. In human atrial fibers, diastolic depolarization (DD) was consistently present, but did not induce spontaneous discharge. Epinephrine enhanced DD, could induce delayed afterdepolarizations (DADs) and (in combination with strophanthidin) trigger repetitive activity. The presence of DD modified the recovery of premature action potentials. Human ventricular fibers did not exhibit DD and were more resistent to Ca overload. It is concluded that in atrial tissues the presence of DD may not induce automatic arrhythmias, but it may influence conduction and re-entry rhythms. Cardioactive drugs may induce DADs and repetitive activity in the atria and less easily in the ventricles. The attainment of a threshold may be facilitated when DADs are superimposed.

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          Author and article information

          Journal
          Journal ID (publisher-id): CRD
          Journal ID (nlm-ta): Cardiology
          Journal ID (doi): 10.1159/issn.0008-6312
          Title: Cardiology
          Publisher: S. Karger AG
          ISSN (Print): 0008-6312
          ISSN (Electronic): 1421-9751
          Publication date Subscription-year: 1992
          Publication date (Print): 1992
          Publication date (Electronic): 12 November 2008
          Volume: 80
          Issue: 3-4
          Pages: 205-214
          Affiliations
          Departments of Internal Medicine and Pharmacology, National Defense Medical Center, and Clinical Research Center at the Veterans General Hospital, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
          Article
          Publisher ID: 175004 Other ID: Cardiology 1992;80:205–214
          DOI: 10.1159/000175004
          PubMed ID: 1511467
          SO-VID: a1eb23e8-e3d1-4d33-845a-e33bac5b4e5a
          Copyright © © 1992 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 28 November 1991
          Date accepted : 06 January 1992
          Page count
          Pages: 10
          Categories
          Subject: Arrhythmias, Electrophysiology and Electrocardiography

          ScienceOpen disciplines: General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Keywords: Diastolic depolarization,Human ventricular tissues,Epinephrine,Mechanical activity,Human atrial tissue,Strophanthidin,Delayed afterdepolarizations,Triggered activity,Electrical activity
          Data availability:
          ScienceOpen disciplines: General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology
          Keywords: Diastolic depolarization, Human ventricular tissues, Epinephrine, Mechanical activity, Human atrial tissue, Strophanthidin, Delayed afterdepolarizations, Triggered activity, Electrical activity

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