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      Genome regulation by polycomb and trithorax proteins.

      Cell

      genetics, metabolism, Drosophila Proteins, Epigenesis, Genetic, Evolution, Molecular, Gene Expression Regulation, Developmental, Histones, Humans, Polycomb-Group Proteins, RNA Interference, physiology, RNA, Untranslated, Repressor Proteins, Animals, Chromosomal Proteins, Non-Histone

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          Abstract

          Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.

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          Journal
          10.1016/j.cell.2007.02.009
          17320510

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