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      The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study.

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          Abstract

          Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.

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          Author and article information

          Journal
          Lancet Respir Med
          The Lancet. Respiratory medicine
          Elsevier BV
          2213-2600
          2213-2600
          Apr 2013
          : 1
          : 2
          Affiliations
          [1 ] Department of Radiology, University of British Columbia, Vancouver, Canada. Electronic address: Harvey.coxson@vch.ca.
          [2 ] Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
          [3 ] GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
          [4 ] Thorax Institute, Hospital Clinic, IDIBAPS, University of Barcelona, and CIBER Enfermedades Respiratorias (CIBERES), Mallorca, Spain.
          [5 ] Institute of Internal Medicine, University of Bergen, Bergen, Norway.
          [6 ] University of Liverpool, Liverpool, UK.
          [7 ] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
          [8 ] University of Cambridge, Cambridge, UK.
          [9 ] Department of Radiology, University of British Columbia, Vancouver, Canada.
          [10 ] University of Edinburgh, Edinburgh, UK.
          [11 ] GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
          [12 ] University of Nebraska Medical Center, Omaha, Nebraska, USA.
          [13 ] Maastricht University Medical Center, Maastricht, The Netherlands.
          [14 ] Odense University Hospital, University of Southern Denmark, Odense, Denmark; University of Manchester, Manchester, UK.
          Article
          S2213-2600(13)70006-7
          10.1016/S2213-2600(13)70006-7
          24429093
          a1fc9a47-6605-48f6-b825-89a9f55925aa
          History

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