42
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

      Science (New York, N.Y.)

      Animals, Antigens, Neoplasm, immunology, Cancer Vaccines, administration & dosage, Carcinoma, Lewis Lung, pathology, therapy, Carcinoma, Pancreatic Ductal, Cell Hypoxia, Cell Line, Tumor, Cell Survival, Gelatinases, metabolism, Immune Tolerance, Interferon-gamma, Membrane Proteins, Mice, Mice, Transgenic, Necrosis, Neoplasm Transplantation, Serine Endopeptidases, Stromal Cells, Tumor Microenvironment, Tumor Necrosis Factor-alpha

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibroblast activation protein-α (FAP). We created a transgenic mouse in which FAP-expressing cells can be ablated. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-γ and tumor necrosis factor-α. Depleting FAP-expressing cells in a subcutaneous model of pancreatic ductal adenocarcinoma also permitted immunological control of growth. Therefore, FAP-expressing cells are a nonredundant, immune-suppressive component of the tumor microenvironment.

          Related collections

          Author and article information

          Journal
          21051638
          10.1126/science.1195300

          Comments

          Comment on this article