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      A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels

      , , ,
      Neuron
      Elsevier BV

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          Abstract

          Proper ion channel function often requires specific combinations of pore-forming alpha and regulatory beta subunits, but little is known about the mechanisms that regulate the surface expression of different channel combinations. Our studies of ATP-sensitive K+ channel (K(ATP)) trafficking reveal an essential quality control function for a trafficking motif present in each of the alpha (Kir6.1/2) and beta (SUR1) subunits of the K(ATP) complex. We show that this novel motif for endoplasmic reticulum (ER) retention/retrieval is required at multiple stages of K(ATP) assembly to restrict surface expression to fully assembled and correctly regulated octameric channels. We conclude that exposure of a three amino acid motif (RKR) can explain how assembly of an ion channel complex is coupled to intracellular trafficking.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          08966273
          March 1999
          March 1999
          : 22
          : 3
          : 537-548
          Article
          10.1016/S0896-6273(00)80708-4
          10197533
          a20c9d77-efc4-4b9a-aa5a-e42817456848
          © 1999

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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