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      Antibody responses to lytic and latent human herpesvirus 8 antigens among HIV-infected patients in central China.

      1 , , , ,
      Bioscience trends

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          Abstract

          Human herpesvirus 8 (HHV8) is an important opportunistic infection of HIV/AIDS. However, very little is known about antibody seropositivities to HHV8 lytic and latent antigens among HIV-infected patients in China. Therefore, a cross-sectional study was conducted to explore HHV8 serostatus among 316 HIV-infected patients in a rural area of central China. The antibody seropositivity to HHV8 ORF65 (lytic) and LANA (latent) antigens was 12.7% and 10.4%, respectively. Patients who were naïve to antiretroviral therapy (ART) were more likely to be seropositive for antibodies to ORF65 (OR: 3.79; 95% CI: 1.71-8.42) and LANA (OR: 3.77; 95% CI: 1.55-9.14) than patients receiving ART. Patients having CD4+ cell counts less than 200 cells/mm3 were more likely to be seropositive for LANA antibody (OR: 3.53; 95% CI: 1.44-8.64) and to have lower LANA antibody titer (p = 0.007). They were also more likely to be seropositive for ORF65 antibody (OR: 2.12; 95% CI: 0.94-4.78) and to have a lower ORF65 antibody titer (p = 0.065), though the difference was marginally significant. No associations between other viral coinfections studied and antibody seropositivity to either latent or lytic HHV8 antigens were identified. Study findings suggest that antibody responses to both lytic and latent HHV8 antigens among HIV patients in China were fairly high and were associated with immunodeficiency status and ART.

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          Author and article information

          Journal
          Biosci Trends
          Bioscience trends
          1881-7823
          1881-7815
          Jun 2012
          : 6
          : 3
          Affiliations
          [1 ] Department of Epidemiology, School of Public Health, Fudan University, Key Laboratory of Public Health Safety of the Ministry of Education, Shanghai, China.
          Article
          554 NIHMS575960
          4016802
          22890160
          a237e3b0-ec47-4799-9aed-f6994eea144b
          History

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