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Acquired Resistance to Immune Checkpoint Inhibitors
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Abstract
<p class="first" id="P1">Immune checkpoint inhibitors (ICI) have rapidly altered the
treatment landscape for
multiple tumor types, providing unprecedented survival in some patients. Despite the
characteristic durability of response to ICI, unfortunately many patients with initial
response will later develop acquired resistance. The current understanding of mechanisms
of acquired resistance to ICIs is remarkably limited, perhaps restraining effective
development of next-generation immunotherapies. Here, we examine the barriers to progress
and emerging clinical reports interrogating acquired resistance with the goal to facilitate
efforts to overcome acquired resistance to ICIs in the future.
</p>